IL17C Polyclonal Antibody, AbBy Fluor™ 750 Conjugated
Product Specifications
Background
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Synonyms
CX2; IL-17C; Interleukin-17C; Cytokine CX2; IL17C; UNQ561/PRO1122
Gene ID
27189
Swiss Prot
Q9P0M4
Cellular Locus
Secreted
Host
Rabbit
Cross Reactivity
Human, Rat
Immunogen
101-197/197
Target
IL17C
Clonality
Polyclonal
Conjugation
AbBy Fluor™ 750
Source
KLH conjugated synthetic peptide derived from human IL-17C
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
749nm/775nm
Concentration
1ug/ul
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Mouse, Dog, Cow, Horse, Rabbit
Gene ID URL
27189
Isotype
IgG
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
