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ERG/KCNH2 Polyclonal Antibody, HRP Conjugated

Product Specifications

Background

The potassium voltage gated channel, subfamily H (eag related), member 2 (KCNH2) gene encodes a voltage-gated potassium channel which has an important role in cardiac action potential repolarization in the mammalian heart. Mutations in KCNH2 have been shown to cause chromosome 7-linked congenital long QT syndrome, a disorder associated with delayed cardiac repolarization, prolonged electrocardiographic QT intervals, and the development of ventricular arrhythmias. KCNH2 channels are an important target for many drugs, and have emerged as a significant type of cardiac ion channel.Highly expressed in heart and brain.

Synonyms

ERG; ERG1; H ERG; HERG 1; HERG; HERG1; LQT 2; LQT2; Potassium channel HERG; SQT1; Voltagegated potassium channel, subfamily H, member 2; KCNH2_HUMAN.

Gene ID

3757

Swiss Prot

Q12809

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Mouse

Immunogen

751-850/1159

Target

ERG/KCNH2

Clonality

Polyclonal

Conjugation

HRP

Source

KLH conjugated synthetic peptide derived from human ERG/KCNH2

Applications

WB, IHC-P, IHC-F

Purification

Purified by Protein A.

Concentration

1ug/ul

Dilution

WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Prediction Reactivity

Human, Rat, Dog, Cow, Sheep, Pig, Horse, Rabbit

Gene ID URL

3757

Isotype

IgG

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