Polycystin 1 Polyclonal Antibody

Product Specifications

Background

Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity) . May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

Synonyms

PBP; Pc-1; TRPP1; Polycystin-1; Autosomal dominant polycystic kidney disease 1 protein; PKD1

Gene ID

5310

Swiss Prot

P98161

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human

Immunogen

131-230/4303

Target

Polycystin 1

Clonality

Polyclonal

Conjugation

Unconjugated

Source

KLH conjugated synthetic peptide derived from human Polycystin 1

Applications

WB, ELISA, FCM, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1ug/ul

Dilution

WB (1:300-5000), ELISA (1:500-1000), FCM (1:20-100), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)