N-Acetylprocainamide (hydrochloride)

N-Acetylprocainamide (Acecainide) hydrochloride is a class III antiarrhythmic, which blocks K+ channels. N-Acetylprocainamide hydrochloride exerts inhibitory effects on the maximum following frequency (MFF) of isolated rabbit atria. N-Acetylprocainamide hydrochloride can be used for the study of arrhythmias[1][2][3].

Product Specifications

CAS Number

[34118-92-8]

Product Name Alternative

Acecainide (hydrochloride) ; NAPA (hydrochloride)

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Drug Metabolite; Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/n-acetylprocainamide-hydrochloride.html

Purity

99.83

Solubility

10 mM in DMSO

Smiles

O=C(NCCN(CC)CC)C1=CC=C(NC(C)=O)C=C1.Cl

Molecular Formula

C15H24ClN3O2

Molecular Weight

313.82

Precautions

H317, H319

References & Citations

[1]Nakahara T, et al. Role of K+ channels in N-acetylprocainamide-induced relaxation of bovine tracheal smooth muscle. Eur J Pharmacol. 2001 Mar 9;415 (1) :73-8.|[2]Minchin RF, et al. Antiarrhythmic potency of procainamide and N-acetylprocainamide in rabbits. Eur J Pharmacol. 1978 Jan 1;47 (1) :51-6. |[3]Okumura K, et al. Effects of N-acetylprocainamide on experimental atrial flutter and atrial electrophysiologic properties in conscious dogs with sterile pericarditis: comparison with the effects of quinidine. J Am Coll Cardiol. 1987 Jun;9 (6) :1332-8.