Notch3 Polyclonal Antibody, Cy3 Conjugated
Product Specifications
Background
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (swissprot) .
Synonyms
HNotch 4; hNotch4; NOTCH 3; NOTCH3; INT 3; INT3; MGC74442; Neurogenic locus notch homolog protein 4; Neurogenic locus notch homolog protein 3; NOTC4_HUMAN; NOTCH-3; NOTCH-4; Notch 4 intracellular domain; Notch homolog 4; NOTCH4 protein; Neurogenic locus notch homolog protein 1; CADASIL; CASIL; Notch homolog 3.
Gene ID
4854
Cellular Locus
Nucleus, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
2001-2100/2318
Target
Notch3
Clonality
Polyclonal
Conjugation
Cy3
Source
KLH conjugated synthetic peptide derived from mouse Notch3
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
512,550nm/570,615nm
Concentration
1ug/ul
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
4854
Isotype
IgG
Curated Selection
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