AD4
AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy[1].
Product Specifications
CAS Number
2918262-09-4
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ad4.html
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H]1[C@@]2([H])[C@]34[C@@](O[C@@H]1OCCN(C(CCCCCCCNC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)CCO[C@H]8O[C@@]9([H])[C@]%10%11[C@](CC[C@H]([C@]%10([H])CC[C@](O9)(OO%11)C)C)([H])[C@H]8C)([H])O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C
Molecular Formula
C55H78N4O15
Molecular Weight
1035.23
References & Citations
[1]Li Y, et al. Facilitated Drug Repurposing with Artemisinin-Derived PROTACs: Unveiling PCLAF as a Therapeutic Target. J Med Chem. 2023 Aug 24;66 (16) :11335-11350..
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
F6992 96 Tests
PARP4 (Poly ADP Ribose Polymerase 4) Rabbit ELISA Kit
Sign In for Pricing
View Details 
B0685 96 Tests
39S ribosomal protein L22 mitochondrial (MRPL22) Human ELISA Kit
Sign In for Pricing
View Details