FHIT Polyclonal Antibody, PE-Cy5 Conjugated
Product Specifications
Background
Cleaves P (1) -P (3) -bis (5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P (1) -P (4) -bis (5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P (1) -P (3) -bis (5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca (2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
Synonyms
FRA3B; AP3Aase; Bis (5'-adenosyl) -triphosphatase; AP3A hydrolase; Diadenosine 5',5'''-P1, P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein; FHIT
Gene ID
2272
Swiss Prot
P49789
Cellular Locus
Cytoplasm
Host
Rabbit
Immunogen
31-147/147
Target
FHIT
Clonality
Polyclonal
Conjugation
PE-Cy5
Source
KLH conjugated synthetic peptide derived from human FHIT
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
488nm/670nm
Concentration
1ug/ul
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Human, Mouse, Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit
Gene ID URL
2272
Isotype
IgG
Curated Selection
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