CBX4 Polyclonal Antibody, Cy7 Conjugated

Product Specifications

Background

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Synonyms

PC2; NBP16; E3 SUMO-protein ligase CBX4; Chromobox protein homolog 4; Polycomb 2 homolog; hPc2; CBX4

Gene ID

8535

Swiss Prot

O00257

Cellular Locus

Nucleus

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Immunogen

401-500/560

Target

CBX4

Clonality

Polyclonal

Conjugation

Cy7

Source

KLH conjugated synthetic peptide derived from human CBX4

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

743nm/767nm

Concentration

1ug/ul

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Prediction Reactivity

Dog, Sheep, Pig, Horse

Gene ID URL

8535

Isotype

IgG

Curated Selection

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