GPR31 Polyclonal Antibody

Product Specifications

Background

High-affinity receptor for 12- (S) -hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE) . 12- (S) -HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.

Synonyms

HETER; HETER1; 12-HETER; 12- (S) -hydroxy-5,8,10,14-eicosatetraenoic acid receptor; 12- (S) -HETE receptor; G-protein coupled receptor 31; GPR31

Gene ID

2853

Swiss Prot

O00270

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human

Immunogen

121-220/319

Target

GPR31

Clonality

Polyclonal

Conjugation

Unconjugated

Source

KLH conjugated synthetic peptide derived from human G protein coupled receptor 31

Applications

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1ug/ul

Dilution

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Gene ID URL

2853

Isotype

IgG

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