APPBP1 Polyclonal Antibody, AbBy Fluor™ 750 Conjugated
Selected Variant
bs-12503R-BF750-TR
Size: 20 µL
Product Specifications
Background
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Synonyms
HPP1; ula-1; APPBP1; A-116A10.1; NEDD8-activating enzyme E1 regulatory subunit; Amyloid beta precursor protein-binding protein 1, 59 kDa; APP-BP1; Amyloid protein-binding protein 1; Proto-oncogene protein 1; NAE1
Gene ID
8883
Swiss Prot
Q13564
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
401-500/534
Target
APPBP1
Clonality
Polyclonal
Conjugation
AbBy Fluor™ 750
Source
KLH conjugated synthetic peptide derived from human APPBP1
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
749nm/775nm
Concentration
1ug/ul
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Dog, Pig, Horse, Rabbit
Gene ID URL
8883
Isotype
IgG
Price
Sign In for Pricing
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNCB0014-500 1x 500 µL
CD31 / PECAM-1 (C31.7), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402399-100 1x 100 µL
TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680956-100 1x 100 µL
UACA / Nucling (AE-5), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC042332-100 1x 100 µL
Thrombomodulin / CD141 (Endothelial Cell Marker) (rTHBD/1591), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC682553-100 1x 100 µL
ATG5 (Autophagy Marker) (ATG5/2553), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details