SPOCK1 Polyclonal Antibody, Cy3 Conjugated
Product Specifications
Background
The Testican family, also designated the BM-40/SPARC/osteonectin family, is composed of highly conserved, extracellular, calcium-binding, sulfate proteoglycans. Expression of Testicans is detected in a variety of tissues, but is most abundant in brain. Family members include Testican-1, Testican-2, Testican-3 and an amino-terminal splice variant of Testican-3, designated N-Tes. Most Testicans inhibit MT-MMPs, thereby inhibiting the activity of pro-MMP-2. Testican-1 is specifically expressed in the thalamus of the brain, and is upregulated in activated astroglial cells of the cerebrum where it mediates neuronal attachment and matrix metalloproteinase activation. After a neural injury, such as a cerebral stroke, Testican-1 expression is upregulated in astrocyte cells in order to inhibit the ability of the protein Neuro-2a to form neurite extensions. Testican-1 is also a component of joint and of the growth plate cartilage that may participate in the regulation of matrix turnover.
Synonyms
Sparc/osteonectin, cwcv and kazal like domains proteoglycan 1; SPOCK; Testican 1; Testican1; Testican-1; ; TIC1; TICN1; TICN1_HUMAN.
Cellular Locus
Secreted, Extracellular matrix
Host
Rabbit
Cross Reactivity
Human
Immunogen
51-150/439
Target
SPOCK1
Clonality
Polyclonal
Conjugation
Cy3
Source
KLH conjugated synthetic peptide derived from human SPOCK1/Testican 1
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
512,550nm/570,615nm
Concentration
1ug/ul
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Mouse, Rat, Dog, Sheep, Pig, Rabbit
Isotype
IgG
Curated Selection
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