Mifamurtide (sodium)

Mifamurtide sodium (MTP-PE sodium), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide sodium is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide sodium has potential for use in rare disease and osteosarcoma research[1][2][3].

Product Specifications

CAS Number

[90825-43-7]

Product Name Alternative

MTP-PE (sodium) ; L-MTP-PE (sodium) ; CGP 19835 (sodium)

UNSPSC

12352211

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mifamurtide-sodium.html

Purity

98.19

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)COP(OCCNC([C@@H](NC(CC[C@@H](NC([C@@H](NC([C@H](O[C@]([C@H](O)[C@H](O)CO)([H])[C@@H](NC(C)=O)C=O)C)=O)C)=O)C(N)=O)=O)C)=O)(O[Na])=O)=O

Molecular Formula

C59H108N6NaO19P

Molecular Weight

1259.48

References & Citations

[1]Kevin Biteau, et al. L-MTP-PE and zoledronic acid combination in osteosarcoma: preclinical evidence of positive therapeutic combination for clinical transfer. Am J Cancer Res. 2016 Feb 15;6 (3) :677-89.|[2]Joseph F Cavallari, et al. Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4. Cell Metab. 2017 May 2;25 (5) :1063-1074.e3.|[3]Francesca Punzo, et al. Mifamurtide and TAM-like macrophages: effect on proliferation, migration and differentiation of osteosarcoma cells. Oncotarget. 2020 Feb 18;11 (7) :687-698.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

NOD2

Citation 01

J Clin Invest. 2024 Oct 1;134 (22) :e179527.|AAPS PharmSciTech. 2024 Nov 26;25 (8) :272.|J Extracell Vesicles. 2025 Aug;14 (8) :e70152.|Res Sq. 2025 Jul 26.|The Ohio State University. 2023 Apr.