NPC2 Polyclonal Antibody, FITC Conjugated
Product Specifications
Background
NPC2 is a secreted protein mapping against gene 14q24.3 (1,2) . NPC2 regulates the lipid composition of sperm membranes during maturation in the epididymis (1,2) . Mutations in the NPC2 gene may cause Nieman-Pick type C2 disease and frontal lobe atrophy (1,2,3) . Nieman-Pick type C2 is a fatal hereditary disease characterized by defective lysosome release of cholesterol (3) . The disease is caused by HE1 deficiency, a lysosmal protein proven to be undetectable in fibroblasts from NPC2 patients (3) . This differentiates NPC2 from NPC1, as NPC1 has HE1 protein present (3) .
Synonyms
EDDM1; Epididymal protein 1; Epididymal secretory protein; Epididymal secretory protein E1; HE1; Human epididymis-specic protein 1; Niemann-Pick disease type C2; Niemann-Pick disease type C2 protein; NPC2; NPC2_HUMAN; Tissue specic secretory protein.
Cellular Locus
Cytoplasm, Secreted
Host
Rabbit
Cross Reactivity
Human
Immunogen
20-80/151
Target
NPC2
Clonality
Polyclonal
Conjugation
FITC
Source
KLH conjugated synthetic peptide derived from human Niemann Pick C2
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
494nm/518nm
Concentration
1ug/ul
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Mouse, Rat, Cow, Sheep
Isotype
IgG
Curated Selection
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