SOX8 Polyclonal Antibody, Cy3 Conjugated
Product Specifications
Background
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
Synonyms
SOX 8; Sox8; SOX8_HUMAN; SRY sex determining region Y box 8; SRY box 8; SRY box containing gene 8; Transcription factor SOX 8; Transcription factor SOX-8; Transcription factor SOX8.
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
101-200/446
Target
SOX8
Clonality
Polyclonal
Conjugation
Cy3
Source
KLH conjugated synthetic peptide derived from human SOX8
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
512,550nm/570,615nm
Concentration
1ug/ul
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Human, Rat, Cow, Horse
Isotype
IgG
Curated Selection
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