KIF5A/NKHC1 Polyclonal Antibody

Product Specifications

Background

NKHC1 is a neuronal-specific component of a multi-subunit molecular motor? complex that mediates intracellular organelle transport. Mutations in the gene encoding NKHC1 cause autosomal dominant spastic paraplegia 10. NKHC1 has a pan-neuronal distribution in the nervous system. Rat tissue extracts by immunoblot of NKHC1 can produce a doublet only in brain and sciatic nerve tissue. NKHC1 is distributed throughout the central nervous system and is enriched in subsets of neurons. Within cultured hippocampal neurons, NKHC1 is concentrated in the perinuclear region of the cell body. Kinesin superfamily proteins like NKHC1 are the molecular motors conveying cargos along microtubules.

Synonyms

NKHC; MY050; SPG10; D12S1889; Kinesin heavy chain isoform 5A; Kinesin heavy chain neuron-specific 1; Neuronal kinesin heavy chain; KIF5A; NKHC1

Gene ID

3798

Swiss Prot

Q12840

Cellular Locus

Cytoplasm

Host

Rabbit

Cross Reactivity

Mouse, Rat

Immunogen

201-300/1032

Target

K5A/NKHC1

Clonality

Polyclonal

Conjugation

Unconjugated

Source

KLH conjugated synthetic peptide derived from human KIF5A/NKHC1

Applications

ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1ug/ul

Dilution

ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Specificity

Belongs to the kinesin-like protein family. Kinesin subfamily. Contains 1 kinesin-motor domain.

Prediction Reactivity

Human, Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit

Gene ID URL

3798

Isotype

IgG

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