CHAPSO
CHAPSO is a bile derivative. CHAPSO reduces protein adsorption, improves the cryo-EM imaging quality. CHAPSO can be used as a detergent, or as the membrane protein solubilization and reconstruction reagent in membrane protein structural studies[1][2][3].
Product Specifications
CAS Number
82473-24-3
Product Name Alternative
3-[3- (Cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulfonate
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/chapso.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(NCCC[N+](C)(C)CC(O)CS(=O)([O-])=O)=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C
Molecular Formula
C32H58N2O8S
Molecular Weight
630.88
Precautions
H302, H315, H319, H335
References & Citations
[1]Li M, et al. Morphological characterization of DMPC/CHAPSO bicellar mixtures: a combined SANS and NMR study. Langmuir. 2013 Dec 23;29 (51) :15943-57.|[2]Chen J, et al. Eliminating effects of particle adsorption to the air/water interface in single-particle cryo-electron microscopy: Bacterial RNA polymerase and CHAPSO. J Struct Biol X. 2019 Jan-Mar;1:100005.|[3]Cladera J, et al., Liposome solubilization and membrane protein reconstitution using Chaps and Chapso. Eur J Biochem. 1997 Feb 1;243 (3) :798-804.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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