TFRC Polyclonal Antibody, Cy3 Conjugated
Product Specifications
Background
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Synonyms
T9; TR; TFR; p90; CD71; TFR1; TRFR; Transferrin receptor protein 1; TFRC
Gene ID
7037
Swiss Prot
P02786
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse
Immunogen
621-720/760
Target
TFRC
Clonality
Polyclonal
Conjugation
Cy3
Source
KLH conjugated synthetic peptide derived from human Transferrin receptor
Applications
WB, IF, Flow-Cyt
Purification
Purified by Protein A.
Excitation Emission
512,550nm/570,615nm
Concentration
1ug/ul
Dilution
WB (1:300-5000), IF (), Flow-Cyt (1ug/Test)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Rat, Dog, Cow, Pig, Horse, Guinea Pig
Gene ID URL
7037
Isotype
IgG
Curated Selection
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