Anabaseine

Anabaseine, a naturally occurring alkaloid toxin, is potent agonist of multiple nicotinic acetylcholine receptors (AChRs) . Anabaseine stimulates the neuromuscular α12β1γδ or α12β1γɛ and α7 AChRs. Anabaseine is also a weak partial agonist at α4β2 nAChRs[1][2][3].

Product Specifications

CAS Number

[3471-05-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/anabaseine.html

Purity

96.0

Solubility

H2O : ≥ 200 mg/mL

Smiles

C1(C2=CC=CN=C2)=NCCCC1

Molecular Formula

C10H12N2

Molecular Weight

160.22

Precautions

H315, H319, H320

References & Citations

[1]Kem W, et al. The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21) : Chemical and Pharmacological Properties. Mar Drugs. 2006;4 (3) :255-273.|[2]Summers KL et al. Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex. Jpn J Pharmacol. 1997 Jun;74 (2) :139-46.|[3]Andrud K, et al. Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine. Mar Drugs. 2019;17 (11) :614. Published 2019 Oct 29.