Anabaseine
Anabaseine, a naturally occurring alkaloid toxin, is potent agonist of multiple nicotinic acetylcholine receptors (AChRs) . Anabaseine stimulates the neuromuscular α12β1γδ or α12β1γɛ and α7 AChRs. Anabaseine is also a weak partial agonist at α4β2 nAChRs[1][2][3].
Product Specifications
CAS Number
3471-05-4
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/anabaseine.html
Purity
96.0
Solubility
H2O : ≥ 200 mg/mL
Smiles
C1(C2=CC=CN=C2)=NCCCC1
Molecular Formula
C10H12N2
Molecular Weight
160.22
Precautions
H315, H319, H320
References & Citations
[1]Kem W, et al. The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21) : Chemical and Pharmacological Properties. Mar Drugs. 2006;4 (3) :255-273.|[2]Summers KL et al. Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex. Jpn J Pharmacol. 1997 Jun;74 (2) :139-46.|[3]Andrud K, et al. Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine. Mar Drugs. 2019;17 (11) :614. Published 2019 Oct 29.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
bs-3800R-PerCP-Cy5.5 100 µL
Ig kappa chain C region Polyclonal Antibody, PerCP-Cy5.5 Conjugated
Sign In for Pricing
View Details AMM18859V 100 µL
MAGEB4 Mouse Monoclonal Antibody [Clone ID: LBI3A3]
Sign In for Pricing
View Details