Lutein

Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health[1]. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS) [2][3]. Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active[4].

Product Specifications

CAS Number

[127-40-2]

Product Name Alternative

Xanthophyll

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Apoptosis; Endogenous Metabolite; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lutein.html

Purity

90.0

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(/C=C/[C@@H](C(C)=C[C@H](O)C1)C1(C)C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C(C(C)(C[C@H](O)C2)C)=C2C

Molecular Formula

C40H56O2

Molecular Weight

568.87

Precautions

H315, H319, H335

References & Citations

[1]Buscemi S, et al. The Effect of Lutein on Eye and Extra-Eye Health.Nutrients. 2018 Sep 18;10 (9) . pii: E1321.|[2]Kim SR, et al. Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin. Exp Eye Res. 2006 May;82 (5) :828-39.|[3]Tan D, et al. Lutein protects against severe traumatic brain injury through anti‑inflammation and antioxidative effects via ICAM‑1/Nrf‑2. Mol Med Rep. 2017 Oct;16 (4) :4235-4240.|[4]Zeni ALB, et al. Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities. Pharmacol Biochem Behav. 2019 Apr;179:63-72.