Dnmt3a Polyclonal Antibody, AbBy Fluor™ 680 Conjugated
Product Specifications
Background
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Synonyms
TBRS; DNMT3A2; M.HsaIIIA; DNA (cytosine-5) -methyltransferase 3A; Dnmt3a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA
Gene ID
1788
Swiss Prot
Q9Y6K1
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
26-100/912
Target
Dnmt3a
Clonality
Polyclonal
Conjugation
AbBy Fluor™ 680
Source
KLH conjugated synthetic peptide derived from human Dnmt3a
Applications
FCM, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
679nm/702nm
Concentration
1ug/ul
Dilution
FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Cow
Gene ID URL
1788
Isotype
IgG
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
040800-ML650 100 µL
RAD52, ID (RAD52, DNA repair protein RAD52 homolog) (MaxLight 650) discontinued
Ask
View Details ![Rabbit Polyclonal PIGY Antibody [Janelia Fluor 646]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
251975-PE 100 µL
SOX15 (SRY (Sex Determining Region Y) -Box 15, SOX20, SOX26, SOX27) (PE)
Ask
View Details