IGF1R Polyclonal Antibody, RBITC Conjugated
Product Specifications
Background
When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
Synonyms
IGFR; CD221; IGFIR; JTK13; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; IGF1R
Gene ID
3480
Swiss Prot
P08069
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Dog
Immunogen
251-350/1367
Target
IGF1R
Clonality
Polyclonal
Conjugation
RBITC
Source
KLH conjugated synthetic peptide derived from human IGF-1R alpha chain
Applications
FCM
Purification
Purified by Protein A.
Excitation Emission
570nm/595nm
Concentration
1ug/ul
Dilution
FCM (1:20-100)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Rat, Cow, Sheep, Pig, Horse, Rabbit
Gene ID URL
3480
Isotype
IgG
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