PKM2 Polyclonal Antibody, AbBy Fluor™ 680 Conjugated
Product Specifications
Background
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Synonyms
PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-3; Pyruvate kinase PKM; Cytosolic thyroid hormone-binding protein; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; Tumor M2-PK; p58; PKM; PK2; Pyruvate kinase PKLR; Pyruvate kinase 1; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase.
Gene ID
5315, 5313
Swiss Prot
P14618, P30613
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
255-350/531
Target
PKM2
Clonality
Polyclonal
Conjugation
AbBy Fluor™ 680
Source
KLH conjugated synthetic peptide derived from mouse Pyruvate kinase PKM
Applications
WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
679nm/702nm
Concentration
1ug/ul
Dilution
WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Cow, Pig, Horse, Rabbit
Gene ID URL
5315, 5313
Isotype
IgG
Curated Selection
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