Recombinant Chinese cobra Cytotoxin 1 protein, N-Trx-His

Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation (By similarity) . It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity and inhibits protein kinases C (PubMed:8448165) . It also binds with high affinity to heparin (PubMed:17685633) .

Recombinant Chinese cobra Cytotoxin 1 protein, N-Trx-His protein is expressed in E.coli with N-Trx-His. It contains the amino acid sequence of 22-81/81.