Recombinant HPV16 E6 protein, N-DsbC-His
Product Specifications
Background
Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.
Gene ID
1489078
Swiss Prot
P03126
Expression System
E.coli
Conjugation
Unconjugated
Tag
N-DsbC-His
Source
Recombinant HPV16 E6 protein, N-DsbC-His protein is expressed in E.coli with N-DsbC-His. It contains the amino acid sequence of 1-158/158.
Applications
ELISA
Endotoxin
Not Tested
Purity
> 95% as determined by SDS- PAGE
Buffer
0.01M TBS (pH7.4)
Storage Conditions
The product should be stored at -70°C or -20°C.
Species
Others
Gene ID URL
1489078
Available Sizes
Frequently Asked Questions
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