Recombinant SARS-COV-2 Spike S1 (N501Y, K417N, E484K) Protein
Product Specifications
Background
SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells. It has been reported that the UK and South African strains may have higher transmission capabilities, eventually in part due to amino acid substitutions on the SARS-CoV-2 Spike protein. The results of a study show the N501Y replacement in this region of the interface (present in both the UK and South African strains) should be favorable for the interaction with ACE2, while the K417N and E484K substitutions (South African strain) would seem neutral or even unfavorable.
Gene ID
YP_009724390.1
Expression System
HEK293
Conjugation
Unconjugated
Tag
His tag
Source
Recombinant SARS-COV-2 Spike S1 (N501Y, K417N, E484K) Protein protein is expressed in HEK293 with His tag. It contains the amino acid sequence of Val16-Arg685.
Applications
WB, ELISA, HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Purity
> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
Buffer
Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4) . 5% trehalose is added as a protectant before lyophilization.
Storage Conditions
The product should be stored at -70°C or -20°C.
Species
SARS-CoV-2
Gene ID URL
YP_009724390.1
Available Sizes
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