Recombinant human MARCH8 protein, APC Conjugated
Product Specifications
Background
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. MARCH8 (membrane-associated ring finger (C3HC4) 8), also known as MIR or RNF178 (RING finger protein 178), is a 291 amino acid multi-pass membrane protein that localizes to vesicle membranes and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, including immature dendritic cells, MARCH8 functions as an E3 ubiquitin ligase that is thought to regulate immune responses by promoting the ubiquitination and subsequent degradation of target proteins, such as B7-2 and CD71.
Gene ID
220972
Swiss Prot
Q5T0T0
Expression System
E.coli
Conjugation
APC
Tag
N-GST&C-His
Source
Recombinant human MARCH8 protein in E.coli with N-GST&C-His. It contains the amino acid sequence of 1-154/291
Applications
Others
Endotoxin
Not Tested
Purity
> 90% as determined by SDS- PAGE
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Species
Others
Gene ID URL
220972
Available Sizes
Curated Selection
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