Recombinant human ZO-1 protein, N-His
Product Specifications
Background
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene ID
7082
Swiss Prot
Q07157
Expression System
E.coli
Conjugation
Unconjugated
Tag
N-His
Source
Recombinant human ZO-1 protein is expressed in E.coli with N-His.
Applications
Others
Endotoxin
Not Tested
Purity
>90% as determined by SDS-PAGE
Buffer
0.01M TBS (pH7.4)
Storage Conditions
The product should be stored at -70°C or -20°C.
Species
Others
Gene ID URL
7082
Available Sizes
Curated Selection
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