Recombinant human RIPK1 protein, N-His
Product Specifications
Background
Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.
Gene ID
8737
Swiss Prot
Q13546
Expression System
E.coli
Conjugation
Unconjugated
Tag
N-His
Source
Recombinant human RIPK1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 327-564/671
Applications
Others
Endotoxin
Not Tested
Purity
> 90% as determined by SDS- PAGE
Buffer
20mM Tris (pH8.0) with 8M Urea.
Storage Conditions
The product should be stored at -70°C or -20°C.
Species
Others
Gene ID URL
8737
Available Sizes
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