Lumacaftor
Lumacaftor (VX-809; VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.
Product Specifications
CAS Number
936727-05-8
Product Name Alternative
VX-809; VRT 826809
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; CFTR
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/VX-809.html
Purity
99.85
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1(F)OC(C=C(C=C2)C3(CC3)C(NC4=NC(C5=CC=CC(C(O)=O)=C5)=C(C=C4)C)=O)=C2O1
Molecular Formula
C24H18F2N2O5
Molecular Weight
452.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Van Goor F, et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A. 2011 Nov 15;108 (46) :18843-8.|[2]Phuan PW, et al. Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol. 2014 Jul;86 (1) :42-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040745-100 1x 100 µL
CD45 / LCA (2B11 + PD7/26), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400009-500 1x 500 µL
MART-1 / Melan-A (M2-7C10), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470026-100 1x 100 µL
ACTH (Adrenocorticotrophic Hormone) (AH26), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC742984-100 1x 100 µL
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details