NPHS2 Monoclonal Antibody
Product Specifications
Background
Podocin is an important member of a group of proteins shown to be associated with the slit diaphragm. Podocin belongs to the band 7 stomatin family of lipid raft-associated proteins. It is a hairpin like integral membrane protein with intracellular N and C termini. Podocin is located at the insertion site of the slit membrane, and is thought to act as a scaffold protein required to maintain or regulate the structural integrity of the slit diaphragm. It plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
Synonyms
Nephrosis 2, idiopathic, steroid resistant; NPHS2 gene; PDCN; Podocin; SRN1; PODO_HUMAN
Gene ID
7827
Swiss Prot
Q9NP85
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
NPHS2
Clonality
Monoclonal
Isotype
IgG
Conjugation
Unconjugated
Applications
WB, IHC-P, IHC-F, IF
Purification
Purified by Protein A.
Concentration
Lot Dependent
Dilution
WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500), IF ()
Buffer
10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
7827
Curated Selection
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