HIF1AN Recombinant Antibody, HRP Conjugated
Product Specifications
Background
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD) . Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins.
Synonyms
FIH 1; FIH1; HIF1AN.
Gene ID
55662
Swiss Prot
Q9NWT6
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Target
HIF1AN
Clonality
Recombinant
Isotype
IgG
Conjugation
HRP
Source
KLH conjugated synthetic peptide derived from human HIF 1 alpha inhibitor
Applications
WB, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
55662
Curated Selection
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