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N-Hydroxyphthalimide (Standard)

N-Hydroxyphthalimide (Standard) is the analytical standard of N-Hydroxyphthalimide. This product is intended for research and analytical applications. N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473). N-Hydroxyphthalimide has anticancer effects against breast and colon cancer[1][2][3].

Product Specifications

CAS Number

524-38-9

UNSPSC

12352005

Target

Akt; Apoptosis; Bcl-2 Family; Biochemical Assay Reagents; Caspase; mTOR; Reference Standards; Survivin

Type

Reference Standards

Related Pathways

Apoptosis; Others; PI3K/Akt/mTOR

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-hydroxyphthalimide-standard.html

Smiles

O=C1C2=C(C(N1O)=O)C=CC=C2

Molecular Formula

C8H5NO3

Molecular Weight

163.13

References & Citations

[1]Bergmeyer H U, et al. Biochemical reagents[M]//Methods of Enzymatic Analysis. Academic Press, 1965: 967-1037.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Isoform

Bcl-xL; Caspase 3; Caspase 9

Available Sizes

Frequently Asked Questions

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