N-Hydroxyphthalimide (Standard)
N-Hydroxyphthalimide (Standard) is the analytical standard of N-Hydroxyphthalimide. This product is intended for research and analytical applications. N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473). N-Hydroxyphthalimide has anticancer effects against breast and colon cancer[1][2][3].
Product Specifications
CAS Number
524-38-9
UNSPSC
12352005
Target
Akt; Apoptosis; Bcl-2 Family; Biochemical Assay Reagents; Caspase; mTOR; Reference Standards; Survivin
Type
Reference Standards
Related Pathways
Apoptosis; Others; PI3K/Akt/mTOR
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/n-hydroxyphthalimide-standard.html
Smiles
O=C1C2=C(C(N1O)=O)C=CC=C2
Molecular Formula
C8H5NO3
Molecular Weight
163.13
References & Citations
[1]Bergmeyer H U, et al. Biochemical reagents[M]//Methods of Enzymatic Analysis. Academic Press, 1965: 967-1037.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Isoform
Bcl-xL; Caspase 3; Caspase 9
Available Sizes
Frequently Asked Questions
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