Thyroglobulin Monoclonal Antibody
Product Specifications
Background
Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) . Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.
Synonyms
AITD 3 antibody, AITD3 antibody, hTG antibody, TDH3 antibody, Tg antibody, TGN antibody, THYG_HUMAN antibody, Thyroglobulin antibody
Gene ID
7038
Swiss Prot
P01266
Cellular Locus
Secreted
Host
Rabbit
Cross Reactivity
Human
Target
Thyroglobulin
Clonality
Monoclonal
Isotype
IgG
Clone
2H4
Conjugation
Unconjugated
Source
Recombinant protein within C-terminal human Thyroglobulin.
Applications
WB, IHC-P, IHC
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IHC ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
7038
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