Cyclin E2 Monoclonal Antibody
Product Specifications
Background
The human Cyclin E2 gene encodes a 404 amino acid protein that is most closely related to Cyclin E. Cyclin E2 mRNA levels peaks at the G1 / S transition. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27 (Kip1) and p21 (Cip1) . Cyclin E2 / Cdk2 phosphorylates histone H1 in vitro. G1 cyclin E controls the initiation of DNA synthesis by activating CDK2. Abnormally high levels of cyclin E expression have frequently been observed in human cancers. Unlike Cyclin E1, which is expressed in great majority of proliferating normal and neoplastically transformed cells, Cyclin E2 levels are low to undetectable in non transformed cells and increase significantly in neoplasm derived cells.
Synonyms
CCN E2 antibody, CCNE 2 antibody, CCNE2 antibody, CCNE2 protein antibody, CYC E2 antibody, CYCE 2 antibody, CYCE2 antibody, CyclinE2 antibody, G1/S specific cyclin E2 antibody
Gene ID
9134
Swiss Prot
O96020
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
Cyclin E2
Clonality
Monoclonal
Isotype
IgG
Clone
4F3
Conjugation
Unconjugated
Source
Recombinant protein
Applications
WB, FCM, IHC-P, IF (ICC), IHC
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IHC-P (1:200-400), IF (ICC) (1:50-200), IHC ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
9134
Curated Selection
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