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Phospho-SIRT1 (Ser47) Recombinant Antibody

Product Specifications

Background

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Synonyms

75SirT1 antibody, hSIR2 antibody, hSIRT1 antibody, HST2, S. cerevisiae, homolog of antibody, NAD dependent deacetylase sirtuin 1 antibody, NAD dependent protein deacetylase sirtuin 1 antibody, OTTHUMP00000198111 antibody, OTTHUMP00000198112 antibody, Regulatory protein SIR2 homolog 1 antibody, SIR1_HUMAN antibody, SIR2 antibody, SIR2 like 1 antibody, SIR2 like protein 1 antibody, SIR2, S.cerevisiae, homolog-like 1 antibody, SIR2-like protein 1 antibody, SIR2ALPHA antibody, SIR2L1 antibody, Sirt1 antibody, SirtT1 75 kDa fragment antibody, Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) antibody, Sirtuin 1 antibody, Sirtuin type 1 antibody

Gene ID

23411

Swiss Prot

Q96EB6

Modification Site

Ser47

Cellular Locus

Cytoplasm, Nucleus

Host

Rabbit

Cross Reactivity

Human

Target

Phospho-SIRT1 (Ser47)

Clonality

Recombinant

Isotype

IgG

Conjugation

Unconjugated

Source

Synthetic phospho-Peptide corresponding to residues surrounding Ser47 of human SIRT1

Applications

WB, IHC-P, IHC-F, IF

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500), IF ()

Buffer

0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

Modification

Phosphorylation

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Gene ID URL

23411

Available Sizes

Curated Selection

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