Phospho-SMC1 (S957) Monoclonal Antibody

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

CDLS2 antibody, DKFZp686L19178 antibody, DXhXs423e antibody, DXS423E antibody, KIAA0178 antibody, MGC138332 antibody, OTTHUMP00000061876 antibody, RP6 29D12.1 antibody, SB1.8 antibody, Segregation of mitotic chromosomes 1 antibody, Segregation of mitotic chromosomes like 1 antibody, SMC 1 antibody, SMC protein 1B antibody, SMC-1-beta antibody, SMC-1B antibody, SMC1 antibody, SMC1A antibody, SMC1alpha antibody, SMC1alpha protein antibody, SMC1B antibody, SMC1B_HUMAN antibody, SMC1BETA antibody, SMC1beta protein antibody, SMC1L1 antibody, SMC1L2 antibody, SMCB antibody, Structural maintenance of chromosome 1 like 1 protein antibody, Structural maintenance of chromosome 1 like 2 protein antibody, Structural maintenance of chromosomes 1A antibody, Structural maintenance of chromosomes 1B antibody, Structural maintenance of chromosomes protein 1B antibody