Phospho-Erk1 (T202) +Erk2 (T185) Monoclonal Antibody
Product Specifications
Background
The protein encoded by this gene is a member of the MAPkinase family. MAP kinases, also known as extracellularsignal-regulated kinases (ERKs), act in a signaling cascade thatregulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to avariety of extracellular signals. This kinase is activated byupstream kinases, resulting in its translocation to the nucleuswhere it phosphorylates nuclear targets. Alternatively splicedtranscript variants encoding different protein isoforms have beendescribed. [provided by RefSeq, Jul 2008].
Gene ID
5595
Swiss Prot
P27361
Modification Site
Thr202+Thr185
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-Erk1 (T202) +Erk2 (T185)
Clonality
Monoclonal
Isotype
IgG
Clone
6H2
Conjugation
Unconjugated
Source
Synthetic phospho-Peptide corresponding to residues surrounding Thr185 of human Erk2.
Applications
WB, IHC-P, IHC-F, IF, Flow-Cyt, ICC/IF
Purification
Purified by Protein A.
Concentration
Lot Dependent
Dilution
WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500), IF (), Flow-Cyt (1ug/Test), ICC/IF (1:50-100)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
5595
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