PSENEN (1D8) Monoclonal Antibody
Product Specifications
Background
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) . Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Synonyms
Gamma-secretase subunit PEN-2; Presenilin enhancer protein 2; PSENEN; PEN2; presenilin enhancer gamma-secretase subunit; MDS033
Gene ID
55851
Swiss Prot
Q9NZ42
Cellular Locus
Cell membrane, Endoplasmic reticulum, Golgi apparatus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
PSENEN
Clonality
Monoclonal
Isotype
IgG
Clone
1D8
Conjugation
Unconjugated
Source
Synthetic peptide corresponding to C-terminal human PEN2.
Applications
WB, FCM, IHC-P, IF (IHC-P), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IHC-P (1:200-400), IF (IHC-P) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
55851
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