FKBP4 (12A5) Monoclonal Antibody
Product Specifications
Background
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) . May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Synonyms
Peptidyl-prolyl cis-trans isomerase FKBP4; 51 kDa FK506-binding protein; 52 kDa FK506-binding protein; 59 kDa immunophilin; FK506-binding protein 4; FKBP59; HSP-binding immunophilin; Immunophilin FKBP52; Rotamase; Peptidyl-prolyl cis-trans isomerase FKBP4 N-terminally processed; PPIase FKBP4; FKBP51; 52 kDa FKBP; FKBP-52; p59; FKBP-4; HBI
Gene ID
2288
Swiss Prot
Q02790
Cellular Locus
Cytoplasm, Nucleus, Mitochondrion, Cytoskeleton
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
FKBP4
Clonality
Monoclonal
Isotype
IgG
Clone
12A5
Conjugation
Unconjugated
Source
Recombinant protein within human FKBP52 aa 1-200.
Applications
WB, FCM, IHC-P, IF (IHC-P), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IHC-P (1:200-400), IF (IHC-P) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
2288
Curated Selection
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