CHAF1A (1D4) Monoclonal Antibody
Product Specifications
Background
Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.
Synonyms
Chromatin assembly factor 1 subunit A; Chromatin assembly factor I p150 subunit; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; hp150; p150 CAF1
Gene ID
10036
Swiss Prot
Q13111
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Target
CHAF1A
Clonality
Monoclonal
Isotype
IgG
Clone
1D4
Conjugation
Unconjugated
Source
Recombinant protein within human p150 CAF1 aa 100-300.
Applications
WB, FCM, IHC-P, IF (IHC-P), IF (ICC), IP
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IHC-P (1:200-400), IF (IHC-P) (1:50-200), IF (ICC) (1:50-200), IP (1-2ug)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
10036
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