Tetranectin (4B3) Monoclonal Antibody
Product Specifications
Background
Tetranectin is a homotrimeric glycoprotein present in plasma and various tissue locations that binds to calcium, heparin, and plasminogen kringle 4. Tetranectin may play a prominent role in tissue remodeling as well as in the regulation of proteolytic processes via its binding and indirect activation of plasminogen. Tetranectin is found in the extracellular matrix (ECM) of certain carcinomas, but is not present in the ECM of normal tissues. Extracellular proteolysis is an important factor in the ability of malignant cells to penetrate normal tissues and metastasize. Decreased plasma tetranectin or increased tetranectin in stroma of cancers correlates with cancer progression and a grim prognosis. Tetranectin may also influence cancer growth by altering activities of plasminogen or the plasminogen fragment, angiostatin which inhibits tumor cell proliferation.
Synonyms
Tetranectin; C-type lectin domain family 3 member B; Plasminogen kringle 4-binding protein; TN; CLEC3B; TNA
Gene ID
7123
Swiss Prot
P05452
Cellular Locus
Secreted
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
CLEC3B
Clonality
Monoclonal
Isotype
IgG
Clone
4B3
Conjugation
Unconjugated
Source
Recombinant protein within human Tetranectin aa 100-250.
Applications
WB, IHC-P, IF (IHC-P), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (IHC-P) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
7123
Curated Selection
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