SNRPA (2A1) Monoclonal Antibody
Product Specifications
Background
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.
Synonyms
U1 small nuclear ribonucleoprotein A; U1 snRNP A; U1-A; U1A; SNRPA
Gene ID
6626
Swiss Prot
P09012
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
SNRPA
Clonality
Monoclonal
Isotype
IgG
Clone
2A1
Conjugation
Unconjugated
Source
Recombinant protein corresponding to N-terminal human U1A.
Applications
WB, IHC-P, IF (ICC), IP, IHC
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (ICC) (1:50-200), IP (1-2ug), IHC ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
6626
Curated Selection
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