STIP1 (2H5) Monoclonal Antibody
Product Specifications
Background
Stress-induced-phosphoprotein 1 (STI1) functions as a co-chaperone for HSP70 and HSP90 during heat shock response. STI1 exists as either a monomer or a dimer, and this conformational flexibility facilitates its function in organizing HSP70/HSP90. HSP90 acts as an ATPase, and requires the recruitment of client proteins and proper conformation to function. STI1 acts as a "scaffold" for client protein recruitment to the relaxed, ADP-bound conformation of HSP90, thus suppressing ATP turnover during the loading phase and allowing proper function.
Synonyms
Stress-induced-phosphoprotein 1; Hsc70/Hsp90-organizing protein; Renal carcinoma antigen NY-REN-11; Transformation-sensitive protein IEF SSP 3521; STI1; Hop; STIP1
Gene ID
10963
Swiss Prot
P31948
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
STIP1
Clonality
Monoclonal
Isotype
IgG
Clone
2H5
Conjugation
Unconjugated
Source
Recombinant protein orresponding to human STIP1 aa 1-150
Applications
WB, FCM, IHC-P
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IHC-P (1:200-400)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
10963
Curated Selection
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