PTGES3 (1A26) Monoclonal Antibody

Product Specifications

Background

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) . Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.

Synonyms

Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23; cPGES; P23; TEBP.

Gene ID

10728

Swiss Prot

Q15185

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

PTGES3

Clonality

Monoclonal

Isotype

IgG

Clone

1A26

Conjugation

Unconjugated

Source

Synthetic peptide within human p23 aa 50-100

Applications

WB, IHC-P, IF (ICC), IP, IHC

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), IHC-P (1:200-400), IF (ICC) (1:50-200), IP (1-2ug), IHC ()

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Gene ID URL

10728

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