CBX3 (4B4) Monoclonal Antibody
Product Specifications
Background
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) . Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
Synonyms
HP1 gamma; Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; Modifier 2 protein; CBX3; HP1-GAMMA; HP1Hs-gamma.
Gene ID
11335
Swiss Prot
Q13185
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
CBX3
Clonality
Monoclonal
Isotype
IgG
Clone
4B4
Conjugation
Unconjugated
Source
Recombinant protein within human CBX3 aa 1-150
Applications
WB, FCM, IHC-P
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IHC-P (1:200-400)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
11335
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