RAPGEF3 (3D1) Monoclonal Antibody
Product Specifications
Background
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Synonyms
Rap guanine nucleotide exchange factor 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; EPAC 1; cAMP-GEFI; RAPGEF3; CGEF1; EPAC; EPAC1; bcm910; HSU79275.
Gene ID
10411
Swiss Prot
O95398
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
RAPGEF3
Clonality
Monoclonal
Isotype
IgG
Clone
3D1
Conjugation
Unconjugated
Source
Recombinant protein within human Epac1 aa 700-900
Applications
WB, IHC-P
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
10411
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