TFAM (16A1) Monoclonal Antibody
Product Specifications
Background
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
Synonyms
Transcription factor A, mitochondrial; Mitochondrial transcription factor 1; Transcription factor 6; Transcription factor 6-like 2; mtTFA; MtTF1; TCF-6; TFAM; TCF6; TCF6L2.
Gene ID
7019
Swiss Prot
Q00059
Host
Rabbit
Cross Reactivity
Human
Target
TFAM
Clonality
Monoclonal
Isotype
IgG
Clone
16A1
Conjugation
Unconjugated
Source
Synthetic peptide within human mtTFA aa 50-150
Applications
WB, IHC-P, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
7019
Curated Selection
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