Angiopoietin 2 (4G2) Monoclonal Antibody
Product Specifications
Background
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Synonyms
Angiopoietin-2; ANG-2; ANGPT2.
Gene ID
285
Swiss Prot
O15123
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
ANGPT2
Clonality
Monoclonal
Isotype
IgG
Clone
4G2
Conjugation
Unconjugated
Source
Human Angiopoietin 2 aa 200-350
Applications
WB, IHC-P
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
285
Curated Selection
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