FMRP (1B6) Monoclonal Antibody

Product Specifications

Background

Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity) . RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly (G), binds moderately to poly (U) but shows very little binding to poly (A) or poly (C) .

Synonyms

Synaptic functional regulator FMR1, Fragile X mental retardation protein 1, FMRP, Protein FMR-1, FMR1

Gene ID

2332

Swiss Prot

Q06787

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

FMRP

Clonality

Monoclonal

Isotype

IgG

Clone

1B6

Conjugation

Unconjugated

Source

Human FMRP aa 1-100

Applications

WB, IHC-P, IF (ICC), IHC

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), IHC-P (1:200-400), IF (ICC) (1:50-200), IHC ()

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C for 12 months.

Gene ID URL

2332

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